Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels.

To the editor: Hypodiploid acute lymphoblastic leukemia (ALL) with <45 chromosomes has been associated with a dismal prognosis.[1][1][⇓][2][⇓][3]-[4][4] Near-haploid (24-31 chromosomes) and low-hypodiploid (32-39 chromosomes) ALL have particularly poor outcomes[5][5],[6][6] and are distinct