Effects of dietary oxidized fish oil on growth performance, antioxidant defense system, apoptosis and mitochondrial function of juvenile largemouth bass (Micropterus salmoides)

Abstract Four isonitrogenous and isolipidic diets containing fresh fish oil (peroxide value, POV: 7.2 meq kg −1 , diet FR) and three degrees of oxidized fish oil (POV: 155, 275 and 564 meq kg −1 , diet OX155, OX275 and OX564, respectively) were formulated to investigate the effects of dietary oxidized fish oil on growth performance, body composition, antioxidant defense system and mitochondrial function of juvenile largemouth bass, Micropterus salmoides . After a 12-week feeding trial, fish fed the OX155 obtained significantly higher ( P 2+ induced swelling of mitochondria also affected by dietary oxidized fish oil. The present study indicated that dietary oxidized fish oil increased oxidative stress, influenced antioxidant system and induced apoptosis of largemouth bass, hepatic mitochondrial function and energy metabolism also were impaired by dietary oxidized fish oil.