Isolation and identification of a new biotransformation compound by Fusarium sacchari from saponin of Panax notoginseng leaves

Objective To study the chemical constituents of transformed products by Fusarium sacchari and to find the rare ginsenosides with anti-tumor effects from the leaves of Panax notoginseng. Methods The compound isolated was separated by repeated silica gel,Sephadex LH-20,and HPLC chromatography. The structure was identified by analysis of its spectral data.Results A dammarane-type triterpene, notoginsenoside-LZ,20(S)-3β-hydroxy-12β,23-epoxy-dammar-24-ene-20-O-β-D-xylopyranosyl (1→6)-β-D-glucopyranoside,was isolated from the transformed products.Conclusion Notoginsenoside-LZ is a new compound.