子宫内膜息肉组织ERα、ERβ、PR及Bcl-2表达及意义

Objective To investigate the expressions and their significance of estrogen receptor α (ERα), estrogen receptor β (ERβ), progesterone receptor (PR) and Bcl-2 in endometrial polyps of women at reproductive age. Methods Endometrium was collected from 110 patients with endometrial polyps (EP) and 45 normal controls. Immunohistochemistry of PV 6000 was used to detect the expressions of ERα, ERβ, PR and Bcl-2, Image Pro Plus 6.0 software was used to analyze the images. Results During proliferative phase, the ERα and ERβ in EP group was not statistically different compared with the control (P＞0.05); whereas PR was significantly lower (t=2.589, P＜0.05) and Bcl-2 was higher (t=2.716, P＜0.01) in the EP group compared with the control. During secretory phase, the ERα and Bcl-2 were higher and PR was lower in the EP group than in the control (t=2.574, 2.581, 2.579; P＜0.05). There was no significant difference in the expression of ERβ between the two groups (P0.05). Conclusion The higher expression of ERα AND Bcl-2, as well as lower expression of PR may contribute to the development of endometrial polyps. ERα might be the major subtype of estrogen receptor playing a critical role in the formation of endometrial polyps.