Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity

Yassine Bouatou,Caroline Flora Samer,Kuntheavy Ing Lorenzini,Youssef Daali,Samira Daou,Marc Fathi,Michela Rebsamen,Jules Alexandre Desmeules,Alexandra Calmy,Monica Escher

Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity

2014

Yassine Bouatou
Caroline Flora Samer
Kuntheavy Ing Lorenzini
Youssef Daali
Samira Daou
Marc Fathi
Michela Rebsamen
Jules Alexandre Desmeules
Alexandra Calmy
Monica Escher

Background Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities.

Keywords:

Drug interaction
Drug
Therapeutic drug monitoring
Voriconazole
Antifungal
Cytochrome P450
Pharmacogenetics
CYP2C19
Pharmacology
Medicine
CYP3A4
Atazanavir
Esomeprazole

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