Pharmacological Investigations on Flowers of Ixora Coccinea

This study was designed to evaluate the analgesic, antidiarrheal and neurophramacological investigations of flower extract of Ixora coccinea in Swiss albino mice following oral administration. In-vivo analgesic activity test was evaluated by acetic acid induced writhing method and tail immersion test. In-vivo anti-diarrheal test was conducted using castor oil-induced method. In-vivo neurophramacological investigations was determined by open field and hole cross test. In-vivo analgesic activity test shows that methanolic extract (50 & 100 mg/kg b.w.) performed good activity in mice comparing to the standard drug diclofenac Na. Methanolic extract of Ixora coccinea displayed a significant and dose dependent antidiarrheal activity against castor oil induced diarrhea on mice. The percent inhibition was 69.23%, 51.78%, 63.63% and 64.91% respectively in the first, second, third and fourth hour in positive control group whereas it was 92.30%, 96.42%, 95.45% and 94.73% in the test group (100mg/Kg body weight). Open field test showed that the depressing action of the extracts was evident from the second observation period in the test animals at the dose of 100 mg / kg body weight. Maximum depressant effect was observed from 2 nd (60 min) to 4 th (120 min) observation period at the dose of 100 mg/kg. The results were dose dependent.