Sustained Release Carbamezapine Matrix Tablets Prepared by Solvent-Evaporation Technique Using Different Polymers

Various formulations of sustained-release matrix tablets of carbamazepine was prepared and evaluated. Tablets were prepared by solvent evaporation method using hydroxy propyl methyl cellulose (HPMC), carboxy methyl cellulose (CMC) and polyvinylpyrrolidon-K90 (PVP-K90), the hydrophilic polymers are used as release sustaining materials. Formulations were designed using drug to polymers ratio 1:1, 1:1.5, 1:2 with a view to develop twice daily sustained release dosage form. Physical properties of co-evaporates and tablets were evaluated. In vitro drug release of the tablets was studied using USP dissolution apparatus I. Drug release data obtained was evaluated by applying various mathematical orders and models to know the release pattern and mechanism of drug release from the matrix tablets. The resulting matrix tablets prepared with all the polymers used in drug to polymer ratio fulfilled all the official requirements for a tablet dosage form except dissolution, while HPMC with drug to polymer ratio 1:2 extend the release of the drug up to 12 hours.