Lithotriptic Activity of Siddha Drug Megarajanga Chooranam on Ethylene Glycol Induced Urolithiasis in Rats

This study was aimed to evaluate the effectiveness of Megarajanga Chooranam [MRC] – A Siddha medicine on albino rats against the development of kidney stones. The activity of Megarajanga Chooranam [MRC] was studied using the ethylene glycol–induced urolithiasis model using Cystone as Standard drug. The Parameters are used including urinary volume, urine pH, urine analysis, and serum analysis to assess the activity. The results indicated that the administration of MRC to rats with ethyleneglycol-induced lithiasis significantly reduced and prevented the growth of urinary stones [p<0.01]. Also the treatment of lithiasis induced rats by MRC restored all the elevated biochemical parameters creatinine, uric acid, and blood urea nitrogen], restored the urine pH to normal and increased the urine volume significantly [p<0.01] when compared to the control drug. Treatment with cystone (750 mg/kg) and MRC reduced the biochemical changes induced by Ethylene glycol. To prove the mechanism by which MRC cures the renal damage caused by ethylene glycol, investigations on levels of various stone inhibitors like total protein, magnesium, and citrate was studied. There was significant rise on total protein, magnesium and citrate after treatment with cystone and MRC and also showed significant decrease in body weight, urine volume and Ph of urine as compared to control group. The study supports the effect of MRC in urolithiasis.