Propofol inhibits gap junctions by attenuating sevoflurane-induced cytotoxicity against rat liver cells in vitro.

BACKGROUNDLiver abnormalities are seen in a small proportion of patients following anaesthesia with sevoflurane.OBJECTIVESTo investigate whether the cytotoxicity of sevoflurane against rat liver cells was mediated by gap junction intercellular communications, and the effect of propofol on sevofluran