Preparation of (2R, 3R, 4R)-3-hydroxy-2,4,6-trimethylheptanoic acid via enzymatic desymmertization

Abstract Synthesis of a unique fatty acyl unit to build the N -terminus of callipeltin A and homophymine B is described. Our approach to access (2 R , 3 R , 4 R )-3-hydroxy-2,4,6-trimethylheptanoic acid uses enzymatic hydrolysis for the desymmetrization of achiral acetate, followed by diastereoselective Roush crotylboration and Wittig olefination for the backbone construction.