NIR-triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-photodynamic Therapy with Inspired Antitumor Immunity.

A desirable cancer therapeutic strategy is supposed to have effective ability to not only exert maximum anticancer ability but also inspire antitumor immunity for preventing tumor relapse and metastasis. During this research, multifunctional upconversion nanoparticles (UCNPs) coated by ROS responsive micelles are prepared for tumor-targeting and near-infrared (NIR)-triggered PDT combined synergistic effect of chemotherapy. Moreover, both PDT and chemotherapy agent could activate antitumor immunity via inducing immunogenic cell death with CD8+ and CD4+ T cells inflitrating in tumors. Through the experiments, intravenous administration of multifunctional nanocarriers with noninvasive NIR irradiation, destroys the orthotopic tumors and efficiently suppresses lung metastasis in a metastatic triple-negative breast cancer model by cascade amplifying chemo-photodynamic therapy and systemic antitumor immunity. In conclusion, this study provides a prospective chemo-photodynamic therapy with inspired antitumor immunity for metastatic cancer treatment.