Red Algae Sulfated Polysaccharides Effervescent Tablets Attenuated Ovalbumin-induced Anaphylaxis by Up-regulating Regulatory T cells in Mouse Models

Red algae sulfated polysaccharides (RASP) were extracted from Porphyra haitanensis and Gracilaria lemaneiformis. RASP were applied to effervescent tablets to develop a type of functional food, termed red algae sulfated polysaccharide effervescent tablets (RASPET), based on the anti-allergic activities of RASP. The anti-allergic activities and the mechanisms of RASPET were investigated in an ovalbumin (OVA)-induced mouse model of food allergy. The results revealed that RASPET alleviated intestinal villi injury by scanning electron microscopy and anaphylactic symptoms, reduced OVA-specific immunoglobulin E, histamine, and mast cell protease-1 levels in the serum, reduced the level of serum interleukin-4, and increased serum interferon-γ level, decreased B cell and mast cell populations. Remarkably, RASPET increased the levels of serum interleukin-10 and transforming growth factor-β and up-regulated splenic CD4+foxp3+ T cell populations (15.28%, 16.82%, and 17.58%, respectively) compared to the OVA-group (13...