Oxadiazole substituted compounds and their use as agonists of S1P1

2011 
A compound of formula (I): Formula ** ** or its stereoisomers, N-oxides or salts; wherein: Ring A is phenyl, thiophenyl, thiazolyl, pyridinyl or pyridinonyl; (I) R1 and R2 are -CH3; or (ii) R1 and R2 together with the carbon atom to which they are attached form a C4-6 cycloalkyl substituted with zero to two Ra; each R3 is independently: (i) F, Cl, C1-4 alkyl, -CF3, -OCH3, -OCF3 and / or -NH 2; and / or (ii) -CH2A1, -OA1, -OCH2A1, -CH2OA1 and / or -CH2SO2A1, where A1 is phenyl, pyridinyl, thiazolyl or imidazolyl substituted with zero to two substituents independently selected from F, Cl, - NH2, C1-2 alkyl, CF3 and / or -OCH3; L1 is - (CR b R) 2-4- or - (CH2) 0-2O (CH2) 1-2-; L2 is a bond; Q is phenyl substituted with zero to three substituents independently selected from F, Cl, -CH3, -CN and / or -CF3; each Ra is independently F and / or -CH3; and / or two Ra attached to the same carbon atom form> = O; and each Rb is independently H, -CH3 and / or -OH, with the proviso that if R is -OH, then the second carbon Rb attached thereto is not -OH or F; n is zero, 1, 2 or 3.
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