(6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists

Dieter Dorsch,Werner Mederski,Norbert Beier,Inge Lues,Klaus-Otto Dr. Minck,Pierre Schelling

(6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists

1994

Dieter Dorsch
Werner Mederski
Norbert Beier
Inge Lues
Klaus-Otto Dr. Minck
Pierre Schelling

The syntheses and angiotensin II antagonistic activities of novel (6-oxo-3-pyridazinyl)-benzimidazole derivatives are reported. Evaluation of the structure-activity relationships led to the discovery of potent orally active antihypertensive compounds.

Keywords:

Antagonist
Angiotensin II
Oral administration
Chemical synthesis
Angiotensin receptor
Renin–angiotensin system
Angiotensin II receptor antagonist
Chemistry
Peptide hormone
Stereochemistry
orally active

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