Hyperhomocyst(e)inemia is an important risk factor for vascular disease in subjects with high-molecular weight apo(a) isoforms : cardiovascular topics
2004
lIgBackground:l/Ig Homocyst(e)ine is reported to increase the
binding of lipoprotein(a) [Lp(a)] to fibrin, which may
increase the thrombogenic effects of Lp(a) in vivo. The
aim of this study was to investigate whether there is
a relationship between homocyst(e)ine and Lp(a) levels
and vascular disease risk, and if the relationship depends
on the apo(a) isoforms.
lbrglIgMethods:l/Ig A case-control study was performed in 91
Caucasian male subjects with vascular disease due to
athersclerosis, and in 100 healthy age- and sex-matched
control subjects.
lbrglIgResults:l/Ig Both hyperhomocyst(e)inemia and elevated
Lp(a) were significantly more prevalent in patients.
Concordant elevated Lp(a) and hyperhomocyst(e)inemia
were not associated with increased vascular disease
risk (relative odds 2.96; 95% CI: 0.90-9.80), while
hyperhomocyst(e)inemia in the absence of elevated
Lp(a) was associated with increased vascular disease
risk (relative odds 7.20; 95% CI: 2.37-21.91).
Hyperhomocyst(e)inemia in individuals with high-molecular
weight apo(a) isoforms [smaller apo(a) isoform
g S3] was observed to be associated with increased
vascular disease risk (relative odds 11.02; 95% CI:
3.54-34.30), while vascular disease risk in subjects with
low-molecular weight apo(a) isoforms [smaller apo(a)
isoform < S3] was not significantly increased, the relative
odds being 1.92; 95% CI: 0.51-7.24.
lbrglIgConclusions:l/Ig We conclude that hyperhomocyst(e)inemia
is an important risk factor in individuals with highmolecular
weight apo(a) isoforms.
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