Research Article COMPARATIVE ANALGESIC ACTIVITY OF TROIS IN RAT FORMALIN TEST

Several topical formulations are available in the market for the management of pain. With the aim of increasing efficacy and decreasing side effects, herbal drugs are being researched for various therapeutic applications This study involved comparison of marketed formulations: Trois, Volini, Moov and Fast-Relief. Trois is a proprietary herbal product indicated for the the management of painful states. The rat formalin test was utilized as the animal model for pain and observations of composite pain score, number of paw licks and pain response latency were recorded in the early and late phases. Results of the present study indicated that Trois was superior in management of acute and chronic pain states as indicated by pain response latency, number of paw licks and composite pain score. Pain scoring indicated that all formulations, except Volini, were significantly better than control in the early phase with Trois showing the highest efficacy. Late phase observations suggested that all formulations were significantly better, with Trois maintaining its higher efficacy. Trois reduced the number of licks and pain response latency to a significant extent in the early and late phases whereas the effect of Moov, Volini and Fast Relief, were significant only in the late phase. Hence, it can be concluded that Trois is a better herbal topical pain relief alternative as compared to other commercial products.