Cover Picture: Eur. J. Immunol. 11/09

This issue's cover features a composite of images showing that cathepsin X promotes co-localization of LFA-1 and α-actinin-1 and are taken from Jevnikar et al. (pp. 3217–3227). In this article, the authors show that cleavage of the three C-terminal amino acids of the β2 cytoplasmic tail of LFA-1 by cathepsin X promotes binding of α-actinin-1 to LFA-1; cathepsin X also enables LFA-1 to transition from its high to intermediate affinity form for ICAM-1. Together, the findings further our understanding of the mechanisms of T-cell migration.