CHRONOTHERAPY: A CONCEPT , PAUPERISM AND APPROCHES

In the modern era of treatment many new approaches have been evolved for more efficient administration of drugs. One of such approach is the administration of drugs at times at which they are most effective and best tolerated. Chronotherapy is the approach where the availability of drug is timed to match rhythms of disease or disorders in order to optimize therapeutic responses and minimize side effects, which makes it a profound and purposeful delivery of medications in unequal amounts over time. Number of systems such as pulsatile drug delivery systems which can use stimuli from magnetic, electric, ultrasound, chemicals, enzymes etc. for drug release in the form of pulse when actually required, core in cup tablets, compression coated/press coated tablets, double coated hard gelatin capsules and double coated tablets, chronomodulating infusion pumps, controlled-release microchip, Layered systems, sigmoidal release systems hydrogels, osmotic drug delivery systems etc have been successfully used for effective chronotherapeutic drug delivery systems.