A three-dimensional human neural cell culture model of Alzheimer’s disease

Se Hoon Choi,Young Hye Kim,Matthias Hebisch,Christopher Sliwinski,Seungkyu Lee,Carla D'Avanzo,Hechao Chen,Basavaraj Hooli,Caroline Asselin,Julien Muffat,Justin B Klee,Can-wen Zhang,Brian J. Wainger,Michael Peitz,Dora M. Kovacs,Clifford J. Woolf,Steven L. Wagner,Rudolph E. Tanzi,Doo Yeon Kim

A three-dimensional human neural cell culture model of Alzheimer’s disease

2014

Se Hoon Choi
Young Hye Kim
Matthias Hebisch
Christopher Sliwinski
Seungkyu Lee
Carla D'Avanzo
Hechao Chen
Basavaraj Hooli
Caroline Asselin
Julien Muffat
Justin B Klee
Can-wen Zhang
Brian J. Wainger
Michael Peitz
Dora M. Kovacs
Clifford J. Woolf
Steven L. Wagner
Rudolph E. Tanzi
Doo Yeon Kim

Early-onset familial Alzheimer’s disease mutations induce both amyloid-β and tau pathologies in differentiated human neural stem cells in 3D cultures.

Keywords:

Neural stem cell
Microtubule-associated protein
Extracellular
Neurite
Cellular differentiation
GSK-3
Presenilin
Cell culture
Cell biology
Biology
Biochemistry of Alzheimer's disease
Tauopathy
Tau protein
Alzheimer's disease
Neurofibrillary tangle
PSEN1

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