Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists

Heterotopic ossification is the conversion of soft tissue into bone, usually after surgery or trauma but also as a result of the genetic disease fibrodysplasia ossificans progressiva. Masahiro Iwamoto and his colleagues have now shown that retinoic receptor-γ agonists ameliorate this condition in mouse models.