SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION oF NOVEL (1,2,4)TRIAZOLO(4,3-C)PYRIMIDIN-3- YL)BENZAMIDE POSSESSING TRI FLUOROMETHYL, FLUORO, NITRO AND MORPHOLINE, THIO MORPHOLINE MOIETIES

Purpose: The article is aimed to synthesize, characterize and screening the biological activity of a series of N-(5-morpholino[1,2,4]triazolo[4,3-0]pyrimidin-3-yl)-4-trifluoromethyl/Fluoro/Nitro/ methoxy) benzamide(7 a-h). Methods: The newly synthesized compounds were characterized by elemental analysis and IR, 1 H-NMR, 13 C NMR and Mass spectral data. The antimicrobial activity of the novel compounds was screened by agar disc diffusion method. Results: 7b, 7d,7a, 7c have shown better antibacterial and anti fungal activity than other compounds of the series. Pyrimidine linked Fused triazoles nucleus has shown good antibacterial and antifungal activities.