In silico modeling system: A national research resource for simulation of complex brain disorders

1. Summary This paper presents the rationale for an initiative to create a comprehensive in silico modeling system, as a national shared resource, for simulation of complex biological systems, eg, neurodegenerative disease. The development of a well-integrated, generally-accessible computer modeling system (built upon a platform of an interlinked network of high performance/super computers -HPC) will enable medical researchers to translate and transform massive amounts of disconnected information (databases) into usable knowledge: an essential initial step for simulating and modeling complex biological processes. The aim of this initiative is to: a) develop a blue print for action and, b) convey the vision of the next generation of research tools, technologies, and systems for the investigation of neurodegenerative disorders of later life. As a first step, a Work Group will be established to: evaluate the infrastructure required for creating a national ‘‘in silico’’ modeling system; consider a number of computer modeling approaches and databases that might be incorporated into a network ofinterconnectedhighperformancecomputingsystems; explore the development of a partnership among the stakeholders (eg, government agencies (NIH, NSF, DOD, DOE and their national labs), universities, pharmaceutical companies, business and finance groups, voluntary private health organizations and foundations); and develop a public policy blueprint to obtain the required funds, research resources and infrastructure to launch the planning and construction of the system.