Impact of salvage surgery and radiotherapy on overall survival in patients with recurrent primary urethral cancer.

4568 Background: To evaluate the impact of salvage therapy (ST) on overall survival (OS) in recurrent primary urethral cancer (PUC). Methods: A series of 154 patients (109 men, 45 women; median age: 66, IQR: 58-76) were diagnosed with PUC at ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank was used to estimate the impact of ST on OS. The median follow-up was 21 months (mean: 32 months; IQR: 4-48). Results: The modality of primary treatment was cystectomy+urethrectomy in 43 (27.9%), total/partial urethrectomy in 39/6 (25.3/3.9%), transurethral resection in 39 (25.3%), chemoradiotherapy (CRT), radiotherapy (RT), chemotherapy (CT) and other in 9 (5.8%), 4 (2.6%), 3 (1.9%) and 9 (5.8%) patients, respectively. Neoadjuvant CT/CRT and adjuvant CT were administered to 16/9 (10.4/5.8%) and 23 (14.9%) patients, respectively. The locations of recurrences were: urethral in 28 (18.2%), lymph nodes (LN) in 18 (11.7%), LN+distant in 12 (7.8%), LN+distant+urethral in 9 (5.8%), LN+urethral i...