Synthesis and Immunosuppressant Activity of Pyrazole Carboxamides.
1999
A series of novel pyrazole carboxamides is disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50 < 1 μM). The synthesis, biological activity, mode of action, and pharmacokinetic properties of this new lead series are discussed.
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