repfdr: a tool for replicability analysis for genome-wide association studies

Motivation: Identification of single nucleotide polymorphisms that are associated with a phenotype in more than one study is of great scientific interest in the genome-wide association studies (GWAS) research. The empirical Bayes approach for discovering whether results have been replicated across studies was shown to be a reliable method, and close to optimal in terms of power. Results: The R package repfdr provides a flexible implementation of the empirical Bayes approach for replicability analysis and metaanalysis, to be used when several studies examine the same set of null hypotheses. The usefulness of the package for the GWAS community is discussed. Availability and implementation: The R package repfdr can be downloaded from CRAN. Contact: ruheller@gmail.com Supplementary information: Supplementary data are available at Bioinformatics online.