Prevention of distortion of vascular deprivation-induced osteonecrosis of the rat femoral head by treatment with alendronate
2009
Introduction
In animals with a disrupted blood supply and drainage of the femoral head, the dead epiphyseal bone undergoes osteoclastic osteolysis and is replaced by newly synthesized, immature, and weak bone, which cannot withstand the daily loads and, therefore, the articular surface caves in.
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