Tetrahydroquinoxaline urea derivatives, their preparation and therapeutic use thereof

The invention relates to compounds of formula (1): wherein A represents a bond, an oxygen or a group -O-CH -; Ar represents a phenyl or heteroaryl group; Ar represents a phenyl, heteroaryl or heterocycloalkyl group; R and R represent hydrogen or halogen or an alkyl, cycloalkyl, -alkyl-cycloalkyl group optionally substituted by one or more halogen atoms, -OR (hydroxy or alkoxy), hydroxy-alkyl, alkoxy-alkyl, alkoxy- alkoxy, haloalkyl, -O-haloalkyl, oxo, -CO-alkyl, -CO-alkyl-NR R, -CO-haloalkyl, -COOR, alkyl-COOR, -O-alkyl-COOR, -SO-alkyl, -SO -cycloalkyl, -SO-alkyl-cycloalkyl, -SO-alkyl-OR, -SO-alkyl-COOR, -SO-alkyl-NR R -SO-haloalkyl, alkyl-SO-alkyl, -SO-NR R, -SO -alkyl-O-alkyl-OR, -CONR R, -alkyl-CONR R or -O-alkyl-NR R, or R, R, R are respectively bonded to R, R, R and to the carbon atom which carries them and represents -O-alkyl-O-; R represents a hydrogen or an alkyl group, R represents a hydrogen or a halogen or a cyano group, -OR, hydroxy-alkyl, -COOR, -NR R, -CONR R, -SO -alkyl or -SO -NR R, -NR-COOR, -NR -COR, -CO-NR -alkyl-OR; R, R and R are hydrogen, alkyl or-alkyl-phenyl, and R is alkyl, alkyl-Si (alkyl); -SO-alkyl-Si (alkyl); phenyl; alkoxyimino; alkyl-cycloalkyl optionally substituted with one or more halogen atoms; heterocycloalkyl substituted with one or more halogen atoms, one or more hydroxy or hydroxyalkyl groups; or R and R together with the carbon atom to which they are bonded form a cycloalkyl group optionally substituted by one or more halogen atoms or one or more carboxy groups; R represents a hydrogen atom or an alkyl group; with the proviso that when R is an alkyl group, it is attached to the silicon atom of Ar. Preparation process and therapeutic application