Novel efficient antimicrobial chlorhexidine acetate nanoemulsion gargle and preparation method thereof

This invention provides an efficient antimicrobial chlorhexidine acetate nanoemulsion gargle and a preparation method thereof. The nanoemulsion gargle provided by the invention is prepared from the following raw and supplemental materials by weight: 0.2-1.5 parts of chlorhexidine acetate, 8-30 parts of a surfactant, 4-15 parts of a cosurfactant, 3-20 parts of an oil phase, 0.05-1 part of an oral cavity refreshing agent, and 34.45-69.0 parts of distilled water. The nanoemulsion gargle provided by the invention can obviously improve the solubility, has extremely stable quality, and especially has the function of obviously enhancing the in vitro and in vivo antimicrobial effect on oral pathogenetic bacteria represented streptococcus mutans and the like by cell membrane destruction. The product provided by the invention has the characteristics of convenient use, low cost, remarkable curative effect, no alcohol, safety and no toxicity, no stimulation, no side effect and no drug resistance, and is a novel oral cavity sterilization, disinfection and cleaning product. The gargle can be widely applied to periodontitis, gingivitis, oral ulcer, dental plaque, dental bleeding, halitosis and other oral diseases.