Comparison of antibody response and related influencing factors after primary immunization by 10 μg hepatitis B vaccine made from recombinant DNA techniques in Saccharomyces and Hansenula polymorpha among adults

乙型肝炎(乙肝)疫苗(HepB)是乙肝防治的有效手段.我国自1992年在新生儿中普种HepB,儿童HBsAg携带率显著下降,但成人HBsAg携带率仍较高.目前我国成人尚无确定的免疫策略,不同种类、剂量HepB的抗体应答仍有争议.本研究对10 μg重组酿酒酵母HepB(HepB-SC)和10μg重组汉逊酵母HepB(HepB-HP)的抗体应答及其影响因素进行观察. 关键词：重组乙型肝炎疫苗(酿酒酵母);重组乙型肝炎疫苗(汉逊酵母);成年人;抗体应答