Direct measurement of myocardial viability by manganese-enhanced MRI (MEMRI) tracks the regenerative effects by human pluripotent stem cell derived cardiomyocytes (hPCMs)

Background Human pluripotent stem cell derived cardiomyocytes (hPCMs) may regenerate the myocardium to restore the cardiac function. Manganese-enhanced MRI (MEMRI) enters the cardiomyocytes via calcium channel to generate viability signal directly. Persistent engraftment of the hPCMs associated with increased myocardial viability and LVEF suggests regeneration. This study tests the hypothesis that hPCMs regenerate the injured murine myocardium.