Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity
2011
Background
Simvastatin is a cholesterol-lowering drug that is widely used to prevent and treat atherosclerotic cardiovascular disease. Simvastatin exhibits numerous pleiotropic effects including anti-cancer activity. However, the effect of simvastatin on cholangiocarcinoma has not been evaluated.
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