Japanese prostate cancer outcome study of permanent I-125 seed implantation (J-POPS study): Interim results of a prospective cohort study assessing efficacy, safety and QOL

16137 Background: Brachytherapy with permanent iodine-125 (I-125) seed implantation has been approved in Japan in July 2003. Multi-institutional cohort study (J-POPS study) assessing the treatment feature, efficacy, safety and health related quality of life (QOL) has begun in July 2005. Over 2,700 patients from 49 institutes are enrolled in this study until the end of October 2007 and finally 8,000 patients in total is expected to be enrolled until the end of 2010. The interim results of this ongoing study have been evaluated. Methods: Forty-three institutions combined data on 1,217 cases treated between July 2005 and February 2007 are analyzed for this interim study. Patient’s background, cancer character, treatment feature such as combined therapy of external beam or hormone, post implantation dosimetric information, treatment efficacy with PSA level, voiding symptoms with IPSS and treatment related adverse events according to NCI- CTCAE are characterized. PSA was measured every 3 months and symptoms ac...