A fluorescent probe for investigating metabolic stability of active transplatin analogues

Abstract Selective fluorescent probes enable unprecedented studies of metals, with sensitivity not only to identify the metal, but also to discern its oxidation state and coordination environment. Recent work has highlighted the potential of fluorescent probes for specific platinum species in understanding the activity of platinum anticancer agents. Here we report a rhodamine-based probe that selectively responds to aryl-bearing trans -platinum complexes, which represent an important class of potential anticancer agents. We subsequently demonstrate the utility of this probe for studying the rate of metabolism of these types of complexes.