Postoperative Empyema following Chronic Subdural Hematoma Surgery: Clinically Based Medicine.

ABSTRACT Introduction: Subdural empyema (SDE) is a rare complication of chronic subdural hematoma (CSDH) surgery. We introduced antibiotic prophylaxis (AP) for this procedure in 2014 following a morbidity-mortality conference (MMC) in our department. We report the results of retrospective data analysis to assess the effect of systematic AP and to identify risk factors for SDE. Material and Methods: Two hundred eight patients were recruited between January 2013 and December 2015; 5 were excluded for incomplete data: 107 without and 96 with AP (n=203). SDE was confirmed by clinical examination, imaging and bacteriological analysis. Comparisons between AP- (no cefuroxime) and AP+ (cefuroxime) groups were made with Chi-square test and Student's t-test. Results: One empyema was found in each group, indicating that AP had no effect (p=1). The only criterion associated with SDE for these two patients was a greater number of reoperations for CSDH recurrence (p=0.013). Discussion: The incidence of postoperative empyema was 1%, similar to the range of 0.2% - 2.1% reported in the literature. This rare incidence explains why we found no significant effect of AP. The medical decision taken at the MMC did not help to reduce the rate of postoperative SDE. MMCs can help to define factors associated with adverse surgical events and identify opportunities for improvement. Conclusion: AP, introduced after an MMC, did not impact SDE rates. In practice, AP should be required only in case of reoperation for CSDH recurrence. However, we still continue to use AP following the MMC considering different parameters discussed in the manuscript.