Human ileal bile acid-binding protein promoter and the effects of CDX2.

Abstract The ileal bile acid-binding protein (IBABP) is important for the reabsorption of bile salts in the distal small intestine. Studies with the human IBABP gene ( FABP6 , on chromosome 5q33.3–q34) defined the major transcription start site and identified conserved elements. A consensus element for the caudal-related homeobox factor CDX2 was functional in gel-shift assays and in transfection experiments.