Study on mRNA expressions of subtypes of somatostatin receptors in gastric carcinoma

OBJECTIVE: To study the expression and distribution of 5 subtypes of somatostatin receptors (SSTR1-5) in gastric carcinoma.METHODS:The mRNA expressions of SSTR1-5 in central and adjacent tissues of gastric carcinoma were detected by RT-PCR technique. RESULTS:Positive expression rates of SSTR1, SSTR2 and SSTR5 mRNA were 100% in central and adjacent tissues of gastric carcinoma, while SSTR3 and SSTR4 mRNA were 79% and 71% in central tissue and 83% and 75% in adjacent tissue of gastric carcinoma, respectively. The mRNA expressions of 5 SSTR in tumor tissue were lower than whose in adjacent tissue, but there was no significant difference between central and adjacent tissues’, P0.05. CONSLUSION:There is mRNA expressions of 5 subtypes of somatostatin receptors in gastric carcinoma, and the mRNA expression of SSTR2 is higher than that of the others.