A Scalable Synthesis of the INOS Inhibitor PHA-399733†

Peter G. M. Wuts,Scott W. Ashford,Brian G. Conway,Jeffrey L. Havens,Bill Taylor,Ben Hritzko,Yanqiao Xiang,Peter S. Zakarias

A Scalable Synthesis of the INOS Inhibitor PHA-399733†

2009

Peter G. M. Wuts
Scott W. Ashford
Brian G. Conway
Jeffrey L. Havens
Bill Taylor
Ben Hritzko
Yanqiao Xiang
Peter S. Zakarias

This contribution describes a scalable synthesis of the INOS inhibitor PHA-399733 using the Bucherer−Bergs hydantoin synthesis to introduce the amino acid function.

Keywords:

Organic chemistry
Amino acid
Chemistry
Hydantoin
inos inhibitor

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