Combined pathology of the pancreas and myocardium in myocardial infarction and acute destructive pancreatitis

: Pancreas was studied in 30 patients who died of myocardial infarction (MI). Total pancreonecrosis was found in 1 case (recurring MI), diffuse focal pancreonecrosis in 3 cases (the second MI). Local microcirculation disturbances, thrombosis of some interlobular veins, degenerative changes of the exocrine pancreocytes with translocation of zymogen granules and their parapedesis into the edematous interstitium were found in all other cases. Focal metabolic myocardial damage and circulation disturbances mainly in the subendocardium of the left ventricle myocardium were found in the heart of 3 patients who died of pancreonecrosis and 60 white rats with pancreatitis induced by chloroethyl. There was a redistribution of Ca2+ in the ultrastructural components of the cardiomyocytes with its accumulation in the cytosol and sarcoplasmic reticulum. The most pronounced and widespread myocardial damage was observed in the hemorrhagic stage of pancreatitis.