Prospective Clinical Study of Nephrotoxicity of Compound Decoction of Caulis Aristolochiae Manshuriensis

To investigate the possible nephrotoxicity of Compound Decoction of Caulis Aristolochiae Manshuriensis (CDCAM). Body weight, blood pressure, hemoglobin and renal functions, especially of urinary low-molecular weight protein in patients were observed before and after a short-term (60d) administration of CDCAM in the dose of less than 6g on the basis of TCM syndrome differentiation.No significant difference of the above indexes were found before and after the administration(P 0.05 ).[Conclusion]The nephrotoxicity of Caulis Aristolochiae Manshuriensis may be associated with the long-term over-dose administration and without TCM syndrome differentiation.