Analysis of the results of 838 cases of myocardial injury markers in neonates

Objective To investigate the diagnostic value and significance of myocardial injury markers in neonates. Methods A retrospective analysis of 838 cases of myocardial injury markers in neonates,the total positive rate of hs-c TnI and the positive rates of hs-c TnI(hypersensitivity cardiac troponin I)in different kinds of neonatal disease were calculated, the levels of abnormalities consistent rate in hs-c TnI and CK-MB-mass(creatine kinase MB mass)were compared with hs-c TnI and MYO(Myoglobin). Results The total positive rate of hs-c TnI was 40.33% in the 838 neonates. The highest incidence of myocardial injury was neonatal sepsis(57.14%), followed by neonatal pulmonary hemorrhage(55.56%)and neonatal convulsions(54.55%). The abnormalities consistent rate of hs-c TnI and CK-MBmass was better than hs-c TnI and MYO(85.50%vs 28.11%,χ2=226.9,P<0.05). Conclusion Neonatal hospitalized children often complicated by myocardial injury; As a biochemical myocardial injury marker,the hs-cTnI detection is important for early detection of myocardial injury, it should be recommend as routine test items; CK-MBmass has better correlation with hs-cTnI than MYO, which can provide guide for doctors to interpret the data of myocardial injury markers. Key words: Myocardial injury markers; hypersensitivitycardiac troponin I