Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors

Schizophrenia has been associated with overactive neuregulin signaling and with glutamatergic synaptic hypoactivity. Now, in brain slice culture experiments, Michael Salter and his colleagues show that neuregulin signaling interferes with Src-induced activation of glutamatergic synaptic activity.