IODOTRIMETHYLSILANE AND CATALYTIC IODINE PROMOTED CYCLIZATION FOR THE FACILE SYNTHESIS OF 3-MONOARYLATED FIVE-MEMBERED BENZOSULTAMS
2010
3-Monoarylated five-membered benzosultams with various functional groups were prepared by simple and convenient two-step procedures. N t-Bu-benzenesulfonamides were lithiated and reacted with substituted aromatic aldehydes to form the corresponding carbinols, which were converted to the cyclic compounds via a sequence of consecutive processes mediated by TMSC1-Nal-MeCN reagent and catalytic amount of iodine. Iodine played a crucial role in the eliminating the reductive side reaction in the cyclization processes.
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