Gastroprotective effect of Achyranthes aspera Linn. leaf on rats.

Abstract Objective The study was aimed at evaluating the antiulcer activity of ethanolic extract of Achyranthes aspera (EEAA) leaf. Methods The anti-ulcer assays were performed on pylorus ligation and chronic ethanol induced ulcer model. The effects of the EEAA on gastric content volume, pH, free acidity, total acidity and ulcer index were evaluated. Results The percentage of ulcer protection (59.55% and 35.58%) was significantly (P Conclusions The results of this study show significant gastroprotective activity of EEAA may be due to presence of phyto-constituents like flavanoids, saponins and tannins.