Syntheses, crystal structures and copper-binding capabilities of amidate-hanging platinum mononuclear complexes containing alkylamine moieties

Abstract As analogs of cis -[Pt(piam) 2 (NH 3 ) 2 ]·2H 2 O ( 1 , piam = pivalamidate), two kinds of platinum mononuclear complexes, cis -[Pt(piam) 2 (NH 2 C 3 H 7 ) 2 ]·H 2 O ( 2 ) and cis -[Pt(piam) 2 (NH 2 C 4 H 9 ) 2 ] ( 3 ), have been synthesized and characterized by single-crystal X-ray analyses. The square-planar complexes 2 and 3 contain propyl and butyl moieties, respectively, enhancing the hydrophobicity. Both compounds have non-coordinated oxygen atoms in the piam ligands that can bind to a second metal, such as the Cu 2+ ion, to afford trinuclear Pt–Cu–Pt complexes. UV–Vis and electron paramagnetic resonance spectra of the reaction of 2 and 3 with the Cu 2+ ion show that both compounds form dinuclear Pt–Cu complexes as intermediates.