A randomized phase II multicenter trial to explore efficacy of weekly intraperitoneal in comparison with intravenous paclitaxel administered immediately after gastrectomy to the patients with high risk of peritoneal recurrence: final results of the INPACT trial

Naoto Takahashi,Mitsuro Kanda,Takaki Yoshikawa,Nobuhiro Takiguchi,Kazumasa Fujitani,Katsufumi Miyamoto,Yuichi Ito,Osamu Takayama,Motohiro Imano,Norio Mitsumori,Junichi Sakamoto,Satoshi Morita,Yasuhiro Kodera

A randomized phase II multicenter trial to explore efficacy of weekly intraperitoneal in comparison with intravenous paclitaxel administered immediately after gastrectomy to the patients with high risk of peritoneal recurrence: final results of the INPACT trial

2018

Naoto Takahashi
Mitsuro Kanda
Takaki Yoshikawa
Nobuhiro Takiguchi
Kazumasa Fujitani
Katsufumi Miyamoto
Yuichi Ito
Osamu Takayama
Motohiro Imano
Norio Mitsumori
Junichi Sakamoto
Satoshi Morita
Yasuhiro Kodera

Background Intraperitoneal administration of paclitaxel had been considered a promising option to treat peritoneal metastasis, the most frequent pattern of recurrence in gastric cancer after D2 gastrectomy, but its safety and efficacy after gastrectomy had not been fully explored.

Keywords:

Medicine
General surgery
Multicenter trial
Gastrectomy
Cancer
Metastasis
Paclitaxel
Surgical oncology
Abdominal surgery
d2 gastrectomy
peritoneal metastasis
Surgery

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