SOLUBLE FORMS OF IMMUNE CHECK-POINT RECEPTOR PD-1 AND ITS LIGAND PD-L1 IN PERIPHERAL BLOOD OF ONCOLOGIC PATIENTS: CLINICAL AND PATHOLOGIC CORRELATIONS

The levels proteins of control points of immunity sPD-1, sPD-L1 in serum or plasma of 366 patients with malignant tumors of various nosological forms treated at the N.N. Blokhin National Medical Research Center of Oncology. A correlation of sPD-L1 with the prevalence of the process and the degree of tumor malignancy, as well as a positive correlation with some other tumor markers of blood, was found: VEGF, VEGFR1, MMP-7, MMP-8, TIMP-1.