Lupus eritematoso neonatal: reporte de un caso

El lupus eritematoso neonatal (LEN) es una enfermedad muy poco frecuente que se presenta en el recien nacido, dada por el pasaje transplacentario de autoanticuerpos anti Ro/SSA, anti La/SSB y U1-RNP. Las principales manifestaciones clinicas son dermatologicas y cardiacas, pudiendo ademas presentar manifestaciones hepaticas, hematologicas y/o neurologicas. Presentamos un caso clinico de un lactante de 3 meses al que se le realizo diagnostico de LEN en base a la presencia de lesiones cutaneas y hallazgos histopatologicos e inmunologicos compatibles, no se acompano de manifestaciones sistemicas y presento una muy buena evolucion posterior. El interes del caso es mostrar una patologia poco frecuente que suele presentarse con lesiones cutaneas caracteristicas, destacando que el pronostico estara determinado por el compromiso cardiaco y que permite en muchos casos realizar diagnostico materno de una enfermedad autoinmune asintomatica. Neonatal lupus erythematosus (LEN) is a rare disease that occurs in the newborn given by the transplacental passage of maternal Anti-Ro/SSA, Anti-La/SSB and Anti-U1-RNP autoantibodies. The main clinical manifestations are dermatologic and cardiac, it may also have hepatic, hematologic or/and neurological ones. The study reports a case of a three month infant who is diagnosed with LEN, based on the presence of consistent findings of skin lesions and histopathology and immunology compatible findings. In this case, it was not accompanied by systemic manifestations evolution was a favorable one. The case is relevant since it presents an unusual condition that is usually accompanied by characteristic skin lesions, where prognosis is determined by cardiac involvement. In many cases, this enables maternal diagnosis of an asymptomatic autoimmune disease.