Capsaicin (8%) patch increases multiple electrical nociceptive thresholds in healthy human subjects

Thresholds are dependent on stimulus properties and are related to different mechanisms in the nociceptive system. Measuring multiple thresholds enables a detailed observation of peripheral and central nociceptive processing. In this study, a model of capsaicin defunctionalization was used to investigate the effect on multiple simultaneously measured electrical nociceptive perception thresholds.With the presented data, increased electrical perception thresholds were observed due to capsaicin. Furthermore, this study confirms that thresholds depend on stimulus parameters. These data can be used to build a mathematical model of the nociceptive system and be used to interpret nociceptive changes.