Deuterated matching preparation of pimozide

2015 
The present invention discloses a method for preparing a deuterated pimozide, the method from 4-fluoro-bromobenzene -d4 After eight-step synthesis reaction process pimozide -d4 horses. The preparation method is provided, of a rational design, easy to operate, easy separation and purification of the product, available raw materials, high yield and purity, high target isotope products obtained, stable isotope labeled prepared homogeneous pimobendan special -d4 can be well applied to the study of the dynamics of clinical pharmacokinetics and thus more accurately and easily understand pimozide in metabolic processes and mechanisms of the human body, and has important application value.
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