Immunosenescence and Cutaneous Malignancies

The increased incidence of skin malignancies in the elderly can be attributed to a myriad of environmental and genetic factors. Among these are the not fully understood cellular and molecular changes of immunosenescence. Understanding how the immune system is dysregulated in advanced age, as well as how it interfaces with the multifaceted roles of the immune system in carcinogenesis and neoplastic control, will aid in developing effective immune strategies and improved therapeutic interventions for skin malignancies in the aging population.